Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells.

ABSTRACT: In the last decade, induced pluripotent stem (iPS) cells have revolutionized the utility of human in vitro models of neurological disease. The iPS-derived and differentiated cells allow researchers to study the impact of a distinct cell type in health and disease as well as performing therapeutic drug screens on a human genetic background. In particular, clinical trials for Alzheimer's disease (AD) have been failing. Two of the potential reasons are first, the species gap involved in proceeding from initial discoveries in rodent models to human studies, and second, an unsatisfying patient stratification, meaning subgrouping patients based on the disease severity due to the lack of phenotypic and genetic markers. iPS cells overcome this obstacles and will improve our understanding of diseas

SUBMITTER: Mungenast AE 

PROVIDER: S-EPMC5930170 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature