Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing.

ABSTRACT: Ebola virus (EBOV) infection is a major public health concern due to high fatality rates and limited effective treatments. Statins, widely used cholesterol-lowering drugs, have pleiotropic mechanisms of action and were suggested as potential adjunct therapy for Ebola virus disease (EVD) during the 2013-2016 outbreak in West Africa. Here, we evaluated the antiviral effects of statin (lovastatin) on EBOV infection in vitro Statin treatment decreased infectious EBOV production in primary human monocyte-derived macrophages and in the hepatic cell line Huh7. Statin treatment did not interfere with viral entry, but the viral particles released from treated cells showed reduced infectivity due to inhibition of viral glycoprotein processing, as evidenced by decreased ratios of the mature gl

SUBMITTER: Shrivastava-Ranjan P 

PROVIDER: S-EPMC5930306 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature