On the Enigma of Glutathione-Dependent Styrene Degradation in Gordonia rubripertincta CWB2.

ABSTRACT: Among bacteria, only a single styrene-specific degradation pathway has been reported so far. It comprises the activity of styrene monooxygenase, styrene oxide isomerase, and phenylacetaldehyde dehydrogenase, yielding phenylacetic acid as the central metabolite. The alternative route comprises ring-hydroxylating enzymes and yields vinyl catechol as central metabolite, which undergoes meta-cleavage. This was reported to be unspecific and also allows the degradation of benzene derivatives. However, some bacteria had been described to degrade styrene but do not employ one of those routes or only parts of them. Here, we describe a novel "hybrid" degradation pathway for styrene located on a plasmid of foreign origin. As putatively also unspecific, it allows metabolizing chemically analogo

SUBMITTER: Heine T 

PROVIDER: S-EPMC5930330 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature