Patients with integrated HPV16 in head and neck cancer show poor survival.

ABSTRACT:

Objectives

We previously reported identifying three categories of HPV16-positive head and neck tumors based on The Cancer Genome Atlas (TCGA) RNA and DNA sequence data. Category 1 had truly integrated HPV16 genomes, category 2 had simple episomal genomes, and category 3 had novel episomes that were a hybrid between viral and human DNA. Using our categorization, we investigated in this study survival of patients with integrated HPV16 tumors versus patients with episomal HPV16 tumors.

Materials and methods

The TCGA RNA-Seq sequence reads were used to quantify HPV E2 and E7 gene expression, which was used as a marker for HPV integration.

Results

The results demonstrate that integration is associated with poor survival; those patients with integrated HPV tumors fared no b

SUBMITTER: Nulton TJ 

PROVIDER: S-EPMC5930384 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature