Proteome Data Improves Protein Function Prediction in the Interactome of Helicobacter pylori.

ABSTRACT: Helicobacter pylori is a common pathogen that is estimated to infect half of the human population, causing several diseases such as duodenal ulcer. Despite one of the first pathogens to be sequenced, its proteome remains poorly characterized as about one-third of its proteins have no functional annotation. Here, we integrate and analyze known protein interactions with proteomic and genomic data from different sources. We find that proteins with similar abundances tend to interact. Such an observation is accompanied by a trend of interactions to appear between proteins of similar functions, although some show marked cross-talk to others. Protein function prediction with protein interactions is significantly improved when interactions from other bacteria are included in our network, a

SUBMITTER: Wuchty S 

PROVIDER: S-EPMC5930399 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature