Comprehensive Redox Profiling of the Thiol Proteome of Clostridium difficile.

ABSTRACT: The strictly anaerobic bacterium C. difficile has become one of the most problematic hospital acquired pathogens and a major burden for health care systems. Although antibiotics work effectively in most C. difficile infections (CDIs), their detrimental effect on the intestinal microbiome paves the way for recurrent episodes of CDI. To develop alternative, non-antibiotics-based treatment strategies, deeper knowledge on the physiology of C. difficile, stress adaptation mechanisms and regulation of virulence factors is mandatory. The focus of this work was to tackle the thiol proteome of C. difficile and its stress-induced alterations, because recent research has reported that the amino acid cysteine plays a central role in the metabolism of this pathogen. We have

SUBMITTER: Sievers S 

PROVIDER: S-EPMC5930413 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature