Mice lacking galectin-3 (Lgals3) function have decreased home cage movement.

ABSTRACT:

Background

Galectins are a large family of proteins evolved to recognize specific carbohydrate moieties. Given the importance of pattern recognition processes for multiple biological tasks, including CNS development and immune recognition, we examined the home cage behavioral phenotype of mice lacking galectin-3 (Lgals3) function. Using a sophisticated monitoring apparatus capable of examining feeding, drinking, and movement at millisecond temporal and 0.5 cm spatial resolutions, we observed daily behavioral patterns from 10 wildtype male C57BL/6J and 10 Lgals3 constitutive knockout (Lgals3^-/-; both cohorts aged 2-3 months) mice over 17 consecutive days. We performed a second behavioral assessment of this cohort at age 6-7 months.

Results

At both ages, Lgals3

SUBMITTER: Chaudoin TR 

PROVIDER: S-EPMC5930520 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature