Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.

ABSTRACT:

Background

Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson's disease (PD). Animal models of PD can serve as a platform to investigate the role of neuroinflammation in degeneration in PD. However, due to features of the previously available PD models, interpretations of the role of neuroinflammation as a contributor to or a consequence of neurodegeneration have remained elusive. In the present study, we investigated the temporal relationship of neuroinflammation in a model of synucleinopathy following intrastriatal injection of pre-formed alpha-synuclein fibrils (α-syn PFFS).

Methods

Male Fischer 344 rats (N = 114) received unilateral intrastriatal injections of α-syn PFFs, PBS, or rat serum albumin with cohorts euthanized at monthly

SUBMITTER: Duffy MF 

PROVIDER: S-EPMC5930695 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature