Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity.

ABSTRACT: SIGNIFICANCE:Hydrogen sulfide (H2S) at the right concentration is associated with numerous health benefits in experimental organisms, ranging from protection from ischemia/reperfusion injury to life span extension. Given the considerable translation potential, two major strategies have emerged: supplementation of exogenous H2S and modulation of endogenous H2S metabolism. Recent Advances: Recently, it was reported that hepatic H2S production capacity is increased in two of the best-characterized mammalian models of life span extension, dietary restriction, and hypopituitary dwarfism, leading to new insights into dietary and hormonal regulation of endogenous H2S production together with broader changes in sulfur amino acid (SAA) metabolism with implications for DNA methylation and redox stat

SUBMITTER: Hine C 

PROVIDER: S-EPMC5930795 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature