Postprandial increase in serum CA125 as a surrogate biomarker for early diagnosis of ovarian cancer.

ABSTRACT:

Background

CA125 is a prevalently used serum biomarker for detecting ovarian cancer over the last three decades. However, it has a significant deficiency in screening for early-stage cancer. With the purpose of exploring an effective approach to improve its performance in early diagnosis, we investigated the postprandial fluctuation pattern of cancer-derived CA125 and the underlying mechanism.

Methods

In two medical centers, 551 patients sonographically diagnosed with ovarian (adnexal) cysts (< 5 cm in diameter) were enrolled and divided into five disease groups (pelvic inflammatory cysts, retention cysts, endometrioma, benign/borderline cystadenoma and malignant cysts). The subtle differences in 1-h postprandial serum CA125 increases were compared between disease groups. A

SUBMITTER: Gu Z 

PROVIDER: S-EPMC5930842 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature