Structural patterns of selection and diversity for Plasmodium vivax antigens DBP and AMA1.

ABSTRACT:

Background

Plasmodium vivax is a significant contributor to the global malaria burden, and a vaccine targeting vivax malaria is urgently needed. An understanding of the targets of functional immune responses during the course of natural infection will aid in the development of a vaccine. Antibodies play a key role in this process, with responses against particular epitopes leading to immune selection pressure on these epitopes. A number of techniques exist to estimate levels of immune selection pressure on particular epitopes, with a sliding window analysis often used to determine particular regions likely to be under immune pressure. However, such analysis neglects protein three-dimensional structural information. With this in mind, a newly developed tool, BioStructMap, was applie

SUBMITTER: Guy AJ 

PROVIDER: S-EPMC5930944 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature