Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes.

ABSTRACT:

Background

Mediator complex (MED) proteins have a key role in transcriptional regulation, some interacting with the oestrogen receptor (ER). Interrogation of the METABRIC cohort suggested that MED7 may regulate lymphovascular invasion (LVI). Thus MED7 expression was assessed in large breast cancer (BC) cohorts to determine clinicopathological significance.

Methods

MED7 gene expression was investigated in the METABRIC cohort (n = 1980) and externally validated using bc-GenExMiner v4.0. Immunohistochemical expression was assessed in the Nottingham primary BC series (n = 1280). Associations with clinicopathological variables and patient outcome were evaluated.

Results

High MED7 mRNA and protein expression was associated with good prognostic factors: low grade, smaller tu

SUBMITTER: Joseph C 

PROVIDER: S-EPMC5931067 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature