Optoacoustics delineates murine breast cancer models displaying angiogenesis and vascular mimicry.

ABSTRACT:

Background

Optoacoustic tomography (OT) of breast tumour oxygenation is a promising new technique, currently in clinical trials, which may help to determine disease stage and therapeutic response. However, the ability of OT to distinguish breast tumours displaying different vascular characteristics has yet to be established. The aim of the study is to prove OT as a sensitive technique for differentiating breast tumour models with manifestly different vasculatures.

Methods

Multispectral OT (MSOT) was performed in oestrogen-dependent (MCF-7) and oestrogen-independent (MDA-MB-231) orthotopic breast cancer xenografts. Total haemoglobin (THb) and oxygen saturation (SO₂^MSOT) were calculated. Pathological and biochemical evaluation of the tumour vascular pheno

SUBMITTER: Quiros-Gonzalez I 

PROVIDER: S-EPMC5931091 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature