Crystal structure of chorismate mutase from Burkholderia thailandensis.

ABSTRACT: Burkholderia thailandensis is often used as a model for more virulent members of this genus of proteobacteria that are highly antibiotic-resistant and are potential agents of biological warfare that are infective by inhalation. As part of ongoing efforts to identify potential targets for the development of rational therapeutics, the structures of enzymes that are absent in humans, including that of chorismate mutase from B. thailandensis, have been determined by the Seattle Structural Genomics Center for Infectious Disease. The high-resolution structure of chorismate mutase from B. thailandensis was determined in the monoclinic space group P2₁ with three homodimers per asymmetric unit. The overall structure of each protomer has the prototypical AroQγ topology and shares conserve

SUBMITTER: Asojo OA 

PROVIDER: S-EPMC5931142 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature