Structure of the tandem PX-PH domains of Bem3 from Saccharomyces cerevisiae.

ABSTRACT: The structure of the tandem lipid-binding PX and pleckstrin-homology (PH) domains of the Cdc42 GTPase-activating protein Bem3 from Saccharomyces cerevisiae (strain S288c) has been determined to a resolution of 2.2 Å (Rwork = 21.1%, Rfree = 23.4%). It shows that the domains adopt a relative orientation that enables them to simultaneously bind to a membrane and suggests possible cooperativity in membrane binding.

SUBMITTER: Ali I 

PROVIDER: S-EPMC5931145 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature