Comorbidities in a community sample of narcolepsy.

ABSTRACT:

Study objective

To assess comorbidities in a community-based cohort of narcolepsy.

Methods

A 2000-2014 community-based narcolepsy cohort was identified in Olmsted County, Minnesota. Records were reviewed by a certified sleep specialist for accuracy of diagnosis, and comorbidities were extracted and analyzed. Comorbidities in narcolepsy subjects, both at diagnosis and upon follow-up, were compared with those in unaffected and age- and sex-matched cohort using conditional logistic regression.

Results

At diagnosis, there was increased association of narcolepsy with anxiety (OR 4.56, 95% CI 1.99-10.44), thyroid disease (3.07, 1.19-7.90), hypertension (2.69, 1.22-5.93), and hyperlipidemia (2.49, 1.05-5.92). At the end of the prolonged observation period of 9.9 years (SD 7.

SUBMITTER: Cohen A 

PROVIDER: S-EPMC5931205 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature