Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine.

ABSTRACT: Amino alcohols are versatile compounds with a wide range of applications. For instance, they have been used as chiral scaffolds in organic synthesis. Their synthesis by conventional organic chemistry often requires tedious multi-step synthesis processes, with difficult control of the stereochemical outcome. We present a protocol to enzymatically synthetize amino alcohols starting from the readily available L-lysine in 48 h. This protocol combines two chemical reactions that are very difficult to conduct by conventional organic synthesis. In the first step, the regio- and diastereoselective oxidation of an unactivated C-H bond of the lysine side-chain is catalyzed by a dioxygenase; a second regio- and diastereoselective oxidation catalyzed by a regiodivergent dioxygenase can lead to the for

SUBMITTER: Fossey-Jouenne A 

PROVIDER: S-EPMC5931277 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature