Profiling of Protein O-GlcNAcylation in Murine CD8⁺ Effector- and Memory-like T Cells.

ABSTRACT: During an acute infection, antigenic stimulation leads to activation, expansion, and differentiation of naïve CD8⁺ T cells, first into cytotoxic effector cells and eventually into long-lived memory cells. T cell antigen receptors (TCRs) detect antigens on antigen-presenting cells (APCs) in the form of antigenic peptides bound to major histocompatibility complex I (MHC-I)-encoded molecules and initiate TCR signal transduction network. This process is mediated by phosphorylation of many intracellular signaling proteins. Protein O-GlcNAc modification is another post-translational modification involved in this process, which often has either reciprocal or synergistic roles with phosphorylation. In this study, using a chemoenzymatic glycan labeling technique and proteomics analysis,

SUBMITTER: Lopez Aguilar A 

PROVIDER: S-EPMC5931335 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature