Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys.

ABSTRACT: Ex vivo normothermic machine perfusion (NMP) is a new clinical strategy to assess and resuscitate organs likely to be declined for transplantation, thereby increasing the number of viable organs available. Short periods of NMP provide a window of opportunity to deliver therapeutics directly to the organ and, in particular, to the vascular endothelial cells (ECs) that constitute the first point of contact with the recipient's immune system. ECs are the primary targets of both ischemia-reperfusion injury and damage from preformed antidonor antibodies, and reduction of perioperative EC injury could have long-term benefits by reducing the intensity of the host's alloimmune response. Using NMP to administer therapeutics directly to the graft avoids many of the limitations associated with system

SUBMITTER: Tietjen GT 

PROVIDER: S-EPMC5931373 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature