Parallel detection in a single ICR cell: Spectral averaging and improved S/N without increased acquisition time.

ABSTRACT: Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) is well-renowned for its ultrahigh resolving power and mass measurement accuracy. As with other types of analytical instrumentation, achievable signal-to-noise ratio (S/N) is an important analytical figure of merit with FTICR-MS. S/N can be improved with higher magnetic fields and longer time-domain signal acquisition periods. However, serial signal averaging of spectra or time-domain signals acquired with multiple ion populations is most commonly used to improve S/N. On the other hand, serial acquisition and averaging of multiple scans significantly increases required data acquisition time and is often incompatible with on-line chromatographic separations. In this study, we investigated the potential for increased S/N

SUBMITTER: Park SG 

PROVIDER: S-EPMC5931402 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature