Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system.

ABSTRACT: Patients born with congenital heart defects frequently encounter arrhythmias due to defects in the ventricular conduction system (VCS) development. Although recent studies identified transcriptional networks essential for the heart development, there is scant information on the mechanisms regulating VCS development. Based on the association of atrial natriuretic peptide (ANP) expression with VCS forming regions, it was reasoned that ANP could play a critical role in differentiation of cardiac progenitor cells (CPCs) and cardiomyocytes (CMs) toward a VCS cell lineage. The present study showed that treatment of embryonic ventricular cells with ANP or cell permeable 8-Br-cGMP can induce gene expression of important VCS markers such as hyperpolarization-activated cyclic nucleotide-gated channe

SUBMITTER: Govindapillai A 

PROVIDER: S-EPMC5932026 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature