CE-BLAST makes it possible to compute antigenic similarity for newly emerging pathogens.

ABSTRACT: Major challenges in vaccine development include rapidly selecting or designing immunogens for raising cross-protective immunity against different intra- or inter-subtypic pathogens, especially for the newly emerging varieties. Here we propose a computational method, Conformational Epitope (CE)-BLAST, for calculating the antigenic similarity among different pathogens with stable and high performance, which is independent of the prior binding-assay information, unlike the currently available models that heavily rely on the historical experimental data. Tool validation incorporates influenza-related experimental data sufficient for stability and reliability determination. Application to dengue-related data demonstrates high harmonization between the computed clusters and the experimental sero

SUBMITTER: Qiu T 

PROVIDER: S-EPMC5932059 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature