Quorum-sensing control of antibiotic resistance stabilizes cooperation in Chromobacterium violaceum.

ABSTRACT: Many Proteobacteria use quorum sensing to regulate production of public goods, such as antimicrobials and proteases, that are shared among members of a community. Public goods are vulnerable to exploitation by cheaters, such as quorum sensing-defective mutants. Quorum sensing- regulated private goods, goods that benefit only producing cells, can prevent the emergence of cheaters under certain growth conditions. Previously, we developed a laboratory co-culture model to investigate the importance of quorum-regulated antimicrobials during interspecies competition. In our model, Burkholderia thailandensis and Chromobacterium violaceum each use quorum sensing-controlled antimicrobials to inhibit the other species' growth. Here, we show that C. violaceum uses quorum sensing to increase resistanc

SUBMITTER: Evans KC 

PROVIDER: S-EPMC5932061 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature