Analysis of Phylogenetic Variation of Stenotrophomonas maltophilia Reveals Human-Specific Branches.

ABSTRACT: Stenotrophomonas maltophilia is a non-fermenting Gram-negative bacterium that is ubiquitous in the environment. In humans, this opportunistic multi-drug-resistant pathogen is responsible for a plethora of healthcare-associated infections. Here, we utilized a whole genome sequencing (WGS)-based phylogenomic core single nucleotide polymorphism (SNP) approach to characterize S. maltophilia subgroups, their potential association with human infection, and to detect any possible transmission events. In total, 89 isolates (67 clinical and 22 environmental) from Germany were sequenced. Fully finished genomes of five strains were included in the dataset for the core SNP phylogenomic analysis. WGS data were compared with conventional genotyping results as well as with underlying diseas

SUBMITTER: Steinmann J 

PROVIDER: S-EPMC5932162 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature