The Interplay of Rogue and Clustered Ryanodine Receptors Regulates Ca²⁺ Waves in Cardiac Myocytes.

ABSTRACT: Ca²⁺ waves in cardiac myocytes can lead to arrhythmias owing to delayed after-depolarisations. Based on Ca²⁺ regulation from the junctional sarcoplasmic reticulum (JSR), a mathematical model was developed to investigate the interplay of clustered and rogue RyRs on Ca²⁺ waves. The model successfully reproduces Ca²⁺ waves in cardiac myocytes, which are in agreement with experimental results. A new wave propagation mode of "spark-diffusion-quark-spark" is put forward. It is found that rogue RyRs greatly increase the initiation of Ca²⁺ sparks, further contribute to the formation and propagation of Ca²⁺ waves when the free Ca²⁺ concentration in JSR lumen ([Ca²⁺]_lumen) is higher than a threshold va

SUBMITTER: Chen X 

PROVIDER: S-EPMC5932313 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature