Antibodies to the Glycoprotein GP2 Subunit Cross-React between Old and New World Arenaviruses.

ABSTRACT: Arenaviruses pose a major public health threat and cause numerous infections in humans each year. Although most viruses belonging to this family do not cause disease in humans, some arenaviruses, such as Lassa virus and Machupo virus, are the etiological agents of lethal hemorrhagic fevers. The absence of a currently licensed vaccine and the highly pathogenic nature of these viruses both make the necessity of developing viable vaccines and therapeutics all the more urgent. Arenaviruses have a single glycoprotein on the surface of virions, the glycoprotein complex (GPC), and this protein can be used as a target for vaccine development. Here, we describe immunization strategies to generate monoclonal antibodies (MAbs) that cross-react between the glycoprotein complexes of both Old World and

SUBMITTER: Amanat F 

PROVIDER: S-EPMC5932378 | biostudies-literature | 2018 May-Jun

REPOSITORIES: biostudies-literature