Influenza Virus: A Master Tactician in Innate Immune Evasion and Novel Therapeutic Interventions.

ABSTRACT: Influenza is a contagion that has plagued mankind for many decades, and continues to pose concerns every year, with millions of infections globally. The frequent mutations and recombination of the influenza A virus (IAV) cast a looming threat that antigenically novel strains/subtypes will rise with unpredictable pathogenicity and fear of it evolving into a pandemic strain. There have been four major influenza pandemics, since the beginning of twentieth century, with the great 1918 pandemic being the most severe, killing more than 50 million people worldwide. The mechanisms of IAV infection, host immune responses, and how viruses evade from such defensive responses at the molecular and structural levels have been greatly investigated in the past 30 years. While this has advanced our underst

SUBMITTER: Hsu AC 

PROVIDER: S-EPMC5932403 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature