From Oxidative Stress Damage to Pathways, Networks, and Autophagy via MicroRNAs.

ABSTRACT: Oxidative stress can alter the expression level of many microRNAs (miRNAs), but how these changes are integrated and related to oxidative stress responses is poorly understood. In this article, we addressed this question by using in silico tools. We reviewed the literature for miRNAs whose expression is altered upon oxidative stress damage and used them in combination with various databases and software to predict common gene targets of oxidative stress-modulated miRNAs and affected pathways. Furthermore, we identified miRNAs that simultaneously target the predicted oxidative stress-modulated miRNA gene targets. This generated a list of novel candidate miRNAs potentially involved in oxidative stress responses. By literature search and grouping of pathways and cellular responses, we could c

SUBMITTER: Engedal N 

PROVIDER: S-EPMC5932428 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature