Mast Cells Exert Anti-Inflammatory Effects in an IL10^-/- Model of Spontaneous Colitis.

ABSTRACT: Mast cells are well established as divergent modulators of inflammation and immunosuppression, but their role in inflammatory bowel disease (IBD) remains to be fully defined. While previous studies have demonstrated a proinflammatory role for mast cells in acute models of chemical colitis, more recent investigations have shown that mast cell deficiency can exacerbate inflammation in spontaneous colitis models, thus suggesting a potential anti-inflammatory role of mast cells in IBD. Here, we tested the hypothesis that in chronic, spontaneous colitis, mast cells are protective. We compared colitis and intestinal barrier function in IL10^-/- mice to mast cell deficient/IL10^-/- (double knockout (DKO): Kit^Wsh/Wsh × IL10^-/-) mice. Compared with IL10

SUBMITTER: Lennon EM 

PROVIDER: S-EPMC5932457 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature