Untangling the complex relationships between incident gout risk, serum urate, and its comorbidities.

ABSTRACT:

Background

Many gout comorbidities (e.g., hypertension) are correlated with serum urate. In this investigation, we identified risk factors (e.g., systolic blood pressure [SBP]), that (1) are associated with incident gout, (2) have effects on gout risk that cannot be fully explained by correlated differences in serum urate, and (3) may modulate the relationship between gout and serum urate.

Methods

Using data from the Atherosclerosis Risk in Communities (ARIC) study, we estimated the unadjusted associations between gout and risk factors by calculating ORs and using chi-square tests. The adjusted associations were analyzed using logistic regression by sequentially adding (1) one risk factor at a time or (2) all risk factors, to a baseline model that includes serum urate only.

SUBMITTER: Sun M 

PROVIDER: S-EPMC5932762 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature