Targeted lipidomics analysis identified altered serum lipid profiles in patients with polymyositis and dermatomyositis.

ABSTRACT:

Background

Polymyositis (PM) and dermatomyositis (DM) are severe chronic autoimmune diseases, characterized by muscle fatigue and low muscle endurance. Conventional treatment includes high doses of glucocorticoids and immunosuppressive drugs; however, few patients recover full muscle function. One explanation of the persistent muscle weakness could be altered lipid metabolism in PM/DM muscle tissue as we previously reported. Using a targeted lipidomic approach we aimed to characterize serum lipid profiles in patients with PM/DM compared to healthy individuals (HI) in a cross-sectional study. Also, in the longitudinal study we compared serum lipid profiles in patients newly diagnosed with PM/DM before and after immunosuppressive treatment.

Methods

Lipidomic profiles were anal

SUBMITTER: Raouf J 

PROVIDER: S-EPMC5932839 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature