Genetic Adaptation to Growth Under Laboratory Conditions in Escherichia coli and Salmonella enterica.

ABSTRACT: Experimental evolution under controlled laboratory conditions is becoming increasingly important to address various evolutionary questions, including, for example, the dynamics and mechanisms of genetic adaptation to different growth and stress conditions. In such experiments, mutations typically appear that increase the fitness under the conditions tested (medium adaptation), but that are not necessarily of interest for the specific research question. Here, we have identified mutations that appeared during serial passage of E. coli and S. enterica in four different and commonly used laboratory media and measured the relative competitive fitness and maximum growth rate of 111 genetically re-constituted strains, carrying different single and multiple mutations. Little overlap

SUBMITTER: Knoppel A 

PROVIDER: S-EPMC5933015 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature