Tubal Ligation Induces Quiescence in the Epithelia of the Fallopian Tube Fimbria.

ABSTRACT: Tubal ligation keeps the fimbriated end of the fallopian tube intact while interrupting the conduit for sperm and egg between the uterus and ovary. Tubal ligation is associated with an approximately 20% decreased risk of high-grade serous ovarian cancers, which mounting evidence suggests arise from the distal fallopian tube epithelium. We postulated that biological changes at the epithelial cellular level of the distal fallopian tube may account for the surgical procedure's observed risk reduction. We compared the histology, presence of epithelial progenitors (basally located CD44-positive cells), and degree of epithelial proliferation (Ki67-positive cells) of distal fallopian tube from 10 patients with previous tubal ligation and 10 age-matched patients with uncut fallopian tubes. A signi

SUBMITTER: Tiourin E 

PROVIDER: S-EPMC5933088 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature