Preeclampsia and Inflammatory Preterm Labor Alter the Human Placental Hematopoietic Niche.

ABSTRACT:

Background

The human placenta is a source of hematopoietic stem and progenitor cells (HSPCs). The RUNX1 transcription factor is required for the formation of functional HSPCs. The impact of preeclampsia (PE) and preterm labor (PTL, spontaneous preterm labor [sPTL] and inflammatory preterm labor [iPTL]) on HSPC localization and RUNX1 expression in the human placenta is unknown.

Methods

We compared the frequency and density of HSPC in control samples from sPTL (n = 6) versus PE (n = 6) and iPTL (n = 6). We examined RUNX1 protein and RNA expression in placentas from normal pregnancies (5-22 weeks, n = 8 total) and in placentas from the aforementioned pregnancy complications (n = 5/group).

Results

Hematopoietic stem and progenitor cells were rare cell types, associated pr

SUBMITTER: Ponder KL 

PROVIDER: S-EPMC5933163 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature