Dysregulation of Lysyl Oxidase Expression in Lesions and Endometrium of Women With Endometriosis.

ABSTRACT:

Unlabelled

Lysyl oxidases (LOXs) are enzymes involved in collagen deposition, extracellular membrane remodeling, and invasive/metastatic potential. Previous studies reveal an association of LOXs and endometriosis. We aimed to identify the mechanisms activated by upregulation of lysyl oxidases (LOX) in endometriotic cells and tissues. We hypothesized that LOX plays a role in endometriosis by promoting invasiveness and epithelial to mesenchymal transition (EMT).

Methods

The LOX protein expression levels were measured by immunohistochemistry in lesions and endometrium on a tissue microarray (TMA) and in endometrial biopsies from patients and controls during the window of implantation (WOI). Estradiol regulation of LOX expression was determined by quantitative polymerase chain r

SUBMITTER: Ruiz LA 

PROVIDER: S-EPMC5933196 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature