Stress-Axis Regulation by Vitamin D₃ in Multiple Sclerosis.

ABSTRACT:

Introduction

Multiple sclerosis (MS) has been associated with both a poor vitamin D status and hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis. Since nuclear receptor ligands may regulate each other, we explored the association of vitamin D₃ supplements with circadian cortisol levels in a double-blind and placebo-controlled supplementation study.

Methods

Female patients with relapsing-remitting MS received vitamin D₃ supplements (4,000 IU/day; n = 22) or placebo (n = 19) during 16 weeks. Salivary cortisol levels, repeatedly measured during the day, and serum 25(OH)D levels were assessed before (T0) and after (T1) this treatment period.

Results

Median 25(OH)D levels at T1 were 139.9 (interquartile range 123.5-161.2) an

SUBMITTER: Rolf L 

PROVIDER: S-EPMC5933207 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature