Systematic Review and Meta-Analysis of Early-Life Exposure to Bisphenol A and Obesity-Related Outcomes in Rodents.

ABSTRACT:

Background

Early-life exposure to bisphenol A (BPA) has been implicated to play a role in the development of obesity.

Objective

A systematic review with meta-analyses of experimental rodent studies was conducted to answer the following question: does early-life exposure to BPA affect the obesity-related outcomes body weight, fat (pad) weight, and circulating and tissue levels of triglycerides, free fatty acids (FFA), and leptin?

Methods

The methodology was prespecified in a rigorous protocol using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) approach. Using PubMed and EMBASE, we identified 61 articles that met the inclusion criteria. The risk of bias and the methodological quality of these articles were assessed using the SYRCLE Risk of

SUBMITTER: Wassenaar PNH 

PROVIDER: S-EPMC5933326 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature