Inhaled corticosteroids and the increased risk of pneumonia: what's new? A 2015 updated review.

ABSTRACT: There is a considerable amount of evidence that supports the possibility of an increased risk of pneumonia associated with prolonged use of inhaled corticosteroids (ICS) in patients with chronic obstructive pulmonary disease (COPD). However, as yet, no statistically significant increase in pneumonia-related 30-day mortality in patients on ICS has been demonstrated. The lack of objective pneumonia definitions and radiological confirmations have been a major source of bias, because of the similarities in clinical presentation between pneumonia and acute exacerbations of COPD. One of the newer fluticasone furoate studies overcomes these limitations and also provides an assessment of a range of doses, suggesting that the therapeutic window is quite narrow and that conventional dosing has proba

SUBMITTER: Iannella H 

PROVIDER: S-EPMC5933605 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature