Genomic evolution of Staphylococcus aureus isolates colonizing the nares and progressing to bacteremia.

ABSTRACT:

Background

Nasal colonization by Staphylococcus aureus is a key risk factor for bacteremia. The objective of this study is to identify genomic modifications occurring in nasal carriage strains of S. aureus as they progress to bacteremia in a cohort of hospitalized patients.

Methods

Eight patients with S. aureus bacteremia were identified. Genomic sequences of the bloodstream isolates were compared with 57 nasal isolates collected longitudinally prior to the occurrence of bacteremia, which covered a timespan of up to 326 days before bacteremia.

Results

Within each subject, nasal colonizing strains were closely related to bacteremia strains. Within a subject, the number of single nucleotide polymorphisms (SNPs) observed between time points was greater than within a sing

SUBMITTER: Benoit JB 

PROVIDER: S-EPMC5933776 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature