Decellularized materials derived from TSP2-KO mice promote enhanced neovascularization and integration in diabetic wounds.

ABSTRACT: Decellularized biologic scaffolds are gaining popularity over synthetic biomaterials as naturally derived materials capable of promoting improved healing. Nevertheless, the most widely used biologic material - acellular dermal matrix (ADM) - exhibits slow repopulation and remodeling, which prevents integration. Additionally, engineering control of these materials is limited because they require a natural source for their production. In the current report, we demonstrate the feasibility of using genetically engineered animals to create decellularized biologic scaffolds with favorable extracellular matrix (ECM) properties. Specifically, we utilized skin from thrombospondin (TSP)-2 KO mice to derive various decellularized products. Scanning electron microscopy and mechanical testing showed th

SUBMITTER: Morris AH 

PROVIDER: S-EPMC5933884 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature