Ontology highlight
ABSTRACT:
SUBMITTER: Tetzlaff F
PROVIDER: S-EPMC5933922 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
eLife 20180405
Angiogenesis is coordinated by VEGF and Notch signaling. DLL4-induced Notch signaling inhibits tip cell formation and vessel branching. To ensure proper Notch signaling, receptors and ligands are clustered at adherens junctions. However, little is known about factors that control Notch activity by influencing the cellular localization of Notch ligands. Here, we show that the multiple PDZ domain protein (MPDZ) enhances Notch signaling activity. MPDZ physically interacts with the intracellular car ...[more]