Ontology highlight
ABSTRACT:
SUBMITTER: Hangauer MJ
PROVIDER: S-EPMC5933935 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature 20171101 7679
Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells. The persister cell pool constitutes a reservoir from which drug-resistant tumours may emerge. Targeting persister cells therefore presents a therapeutic opportunity to impede tumour relapse. We previously found that cancer cells in a high mesenchymal ther ...[more]