Human cardiomyocyte calcium handling and transverse tubules in mid-stage of post-myocardial-infarction heart failure.

ABSTRACT:

Aims

Cellular processes in the heart rely mainly on studies from experimental animal models or explanted hearts from patients with terminal end-stage heart failure (HF). To address this limitation, we provide data on excitation contraction coupling, cardiomyocyte contraction and relaxation, and Ca²⁺ handling in post-myocardial-infarction (MI) patients at mid-stage of HF.

Methods and results

Nine MI patients and eight control patients without MI (non-MI) were included. Biopsies were taken from the left ventricular myocardium and processed for further measurements with epifluorescence and confocal microscopy. Cardiomyocyte function was progressively impaired in MI cardiomyocytes compared with non-MI cardiomyocytes when increasing electrical stimulation towards frequ

SUBMITTER: Hoydal MA 

PROVIDER: S-EPMC5933953 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature