An assessment of candidate genes to assist prognosis in gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is the fourth commonest cancer worldwide, with the second highest mortality rate. Its poor mortality is linked to delayed presentation. There is a drive towards non-invasive biomarker screening and monitoring of many different types of cancer, although with limited success so far. We aimed to determine if any genes from a 32-gene panel could be used to determine GC prognosis.

Methods

We carried out a retrospective study on the expression of 32 genes, selected for their proven or potential links to GC, on historic formalin fixed paraffin-embedded (FFPE) GC specimens from our unit. Gene expression was measured using quantitative nuclease protection assays (qNPA) technology. Following statistical analysis of the results, immunohistochemical staini

SUBMITTER: McFarlane M 

PROVIDER: S-EPMC5934144 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature