Activation of G_αq Signaling Enhances Memory Consolidation and Slows Cognitive Decline.

ABSTRACT: Perhaps the most devastating decline with age is the loss of memory. Therefore, identifying mechanisms to restore memory function with age is critical. Using C. elegans associative learning and memory assays, we identified a gain-of-function G_αq signaling pathway mutant that forms a long-term (cAMP response element binding protein [CREB]-dependent) memory following one conditioned stimulus-unconditioned stimulus (CS-US) pairing, which usually requires seven CS-US pairings. Increased CREB activity in AIM interneurons reduces the threshold for memory consolidation through transcription of a set of previously identified "long-term memory" genes. Enhanced G_αq signaling in the AWC sensory neuron is both necessary and sufficient for improved memory and increased AIM CREB ac

SUBMITTER: Arey RN 

PROVIDER: S-EPMC5934306 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature