Biophysical Modeling of In Vivo Glioma Response After Whole-Brain Radiation Therapy in a Murine Model of Brain Cancer.

ABSTRACT:

Purpose

To develop and investigate a set of biophysical models based on a mechanically coupled reaction-diffusion model of the spatiotemporal evolution of tumor growth after radiation therapy.

Methods and materials

Post-radiation therapy response is modeled using a cell death model (M_d), a reduced proliferation rate model (M_p), and cell death and reduced proliferation model (M_dp). To evaluate each model, rats (n = 12) with C6 gliomas were imaged with diffusion-weighted magnetic resonance imaging (MRI) and contrast-enhanced MRI at 7 time points over 2 weeks. Rats received either 20 or 40 Gy between the third and fourth imaging time point. Diffusion-weighted MRI was used to estimate tumor cell number within enhancing regions in contrast-enhance

SUBMITTER: Hormuth DA 

PROVIDER: S-EPMC5934308 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature