CCDC102B confers risk of low vision and blindness in high myopia.

ABSTRACT: The incidence of high myopia is increasing worldwide with myopic maculopathy, a complication of myopia, often progressing to blindness. Our two-stage genome-wide association study of myopic maculopathy identifies a susceptibility locus at rs11873439 in an intron of CCDC102B (P = 1.77 × 10^-12 and P_corr = 1.61 × 10^-10). In contrast, this SNP is not significantly associated with myopia itself. The association between rs11873439 and myopic maculopathy is further confirmed in 2317 highly myopic patients (P = 2.40 × 10^-6 and P_corr = 1.72 × 10^-4). CCDC102B is strongly expressed in the retinal pigment epithelium and choroids, where atrophic changes initially occur in myopic maculopathy. The development of myopic maculopathy thus lik

SUBMITTER: Hosoda Y 

PROVIDER: S-EPMC5934384 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature