Noncommunicable diseases in adolescents with perinatally acquired HIV-1 infection in high-income and low-income settings.

ABSTRACT:

Purpose of review

Perinatally HIV-infected adolescents may be at increased risk of noninfectious comorbidities later in life. This review summarizes recent advances in the understanding of noncommunicable diseases (NCD) among HIV-infected adolescents in high-income and lower middle-income countries, and identifies key questions that remain unanswered. We review atherosclerotic vascular disease (AVD), chronic bone disease (CBD), chronic kidney disease (CKD), and chronic lung disease (CLD).

Recent findings

Persistent immune activation and inflammation underlie the pathogenesis of AVD, highlighting the importance of treatment adherence and maintenance of viral suppression, and the need to evaluate interventions to decrease risk. Tenofovir disoproxil fumarate (TDF) and trials of

SUBMITTER: Innes S 

PROVIDER: S-EPMC5934760 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature