Larval density mediates knockdown resistance to pyrethroid insecticides in adult Aedes aegypti.

ABSTRACT: BACKGROUND:Understanding mechanisms driving insecticide resistance in vector populations remains a public health priority. To date, most research has focused on the genetic mechanisms underpinning resistance, yet it is unclear what role environmental drivers may play in shaping phenotypic expression. One of the key environmental drivers of Aedes aegypti mosquito population dynamics is resource-driven intraspecific competition at the larval stage. We experimentally investigated the role of density-dependent larval competition in mediating resistance evolution in Ae. aegypti, using knockdown resistance (kdr) as a marker of genotypic resistance and CDC bottle bioassays to determine phenotype. We reared first-instar larvae from susceptible and pyrethroid-resistant field-derived populations of

SUBMITTER: Grossman MK 

PROVIDER: S-EPMC5934844 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature