A validation study of crescents in predicting ESRD in patients with IgA nephropathy.

ABSTRACT:

Background

A working group on the Oxford classification of IgA nephropathy (IgAN) recently reported that crescents detected in kidney tissue predicted a worse renal outcome. However, this finding must be validated in independent cohorts before it can be widely applied to clinical practice.

Methods

Biopsy-proven IgAN patients were continuously recruited from two large renal centers in China from 1989 to 2014. All patients were followed for more than 1 year unless end stage renal disease (ESRD) occurred within 12 months. Crescents were defined as focal cellular or fibrocellular crescent formations. IgAN patients without detectable crescents were recruited to the C0 group. Patients with crescents in less than or more than 1/4 of all glomeruli were recruited to the C1 or C2 grou

SUBMITTER: Zhang X 

PROVIDER: S-EPMC5934890 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature